Cancer Cell Line Genomics
The cancer cell line genome variation data in cncercelllines consists of a mix of whole-genome copy number variation (CNV) profiles - as has been established for the parent Progenetix resource - as well as annotated genome variation data, mapped to genome coordinats and queryable using the Beacon v2 API . The cancercelllines resource contains data of 16178 individual cancer cell lines from 400 different cancer types (NCIt neoplasm classification).
A large amount of the cancer cell line data has been collected based on annotations and pointers from Cellosaurus , a reference knowledge resource on cell lines.
Cell Line Data CNV Frequency Plot The CNV histogram above represents CNV data from a
randomly selected set of samples - either instances of a common cell
line or with a shared diagnosis. In this example the frequencies of
regional gains and losses in 109
samples from NCIT:C166418 (Pancreatobiliary Carcinoma) are on display.
Citation
- cancercelllines.org: Cancer cell line oncogenomic online resource (2023)
- Huang Q, Carrio-Cordo P, Gao B, Paloots R, Baudis M. (2021): The Progenetix oncogenomic resource in 2021. Database (Oxford). 2021 Jul 17